Dextran Sulfate Sodium Inhibits Alanine Synthesis in Caco-2 Cells

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Dextran Sulfate Sodium Inhibits Alanine Synthesis in Caco-2 Cells

To understand and characterize the pathogenic mechanisms of inflammatory bowel disease, dextran sulfate sodium (DSS) has been used to induce acute and chronic colitis in animal models by causing intestinal epithelium damage. The mechanism of action of DSS in producing this outcome is not well understood. In an effort to understand how DSS might impact epithelial cell metabolism, we studied the ...

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In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis.

Pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induces colitis, which exhibit several clinical and histological features for IBD. However, pathogenic factors in the development of colitis remain unclear. Therefore, we investigated possible mechan...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2011

ISSN: 1422-0067

DOI: 10.3390/ijms12042325